The Longevity
Activator.
NAD declines by up to 50% by age 60. Sirtuins … the proteins that govern longevity, mood, focus, and healthy aging — need it to function. Protandim NAD switches them back on.
2x
your body’s own production of sirtuins*
7
sirtuin proteins that govern longevity and healthspanrestored
3rd
pillar of the anti-aging trifecta — with NRF2 + NRF1
HOW IT WORKS
NAD powers your sirtuins. Sirtuins power your lifespan.
Sirtuins are a family of proteins that regulate everything from cellular repair and inflammation to mood, focus, and longevity. They need NAD to function — and NAD declines dramatically with age. Protandim NAD goes beyond simply supplementing NAD. It activates the sirtuin pathways directly, targeting the real goal: longer healthspan at the cellular level.
01
NAD Declines With Age
By your 40s and 50s, NAD levels have dropped significantly — by up to 50% by age 60. Less NAD means less sirtuin activity. Less sirtuin activity means accelerated aging, declining energy, brain fog, and a weaker inflammatory response.
02
Sirtuins Are Longevity Proteins
There are 7 sirtuin proteins in the human body. They govern cellular repair, healthy inflammation, gene expression, autophagy (cellular waste removal), mood, focus, and longevity. They are among the most studied molecules in aging science.
03
Protandim NAD Activates the Pathway
Rather than just topping up NAD levels, Protandim NAD activates genes that are part of the signaling pathways needed to trigger NAD-dependent enzymes and increase sirtuin activity — going Beyond NAD to the real target.
04
The Result: Activated Longevity
More sirtuin activity means better cellular housekeeping, sharper focus, more stable mood, healthier inflammation response, and a body that ages more gracefully from the inside out. This is activated longevity.
THE FORMULA
Four precision ingredients. One activated longevity pathway.
Each ingredient in Protandim NAD was selected for its specific role in supporting NAD synthesis, sirtuin activation, and the signaling pathways that govern how we age.
Theacrine
Similar in structure to caffeine but without the tolerance build-up. Used for centuries to support energy and alertness, Theacrine provides clean, sustained mental energy while supporting liver, kidney, and detoxification pathways.*
Alpha-Lipoic Acid
Rich in oleuropein, olive leaf extract supports a healthy inflammatory response, healthy cholesterol levels already within a normal range, and a balanced gut microbiome — foundational to long-term health.*
Wasabi Rhizome
Rich in isothiocyanates — potent activators of genetic and metabolic processes. Wasabi extract activates many of the same pathways targeted by calorie restriction and fasting, without requiring either.*
Cuprous Niacin
A precursor for NAD synthesis and an essential cofactor for iron metabolism, nerve function, and cellular energy production. Cuprous Niacin directly supports the raw material your body needs for sirtuin activity.*
WHAT NAD ACTIVATION FEELS LIKE
Five benefits of activated sirtuins.
Sirtuins are a family of proteins that regulate everything from cellular repair and inflammation to mood, focus, and longevity. They need NAD to function — and NAD declines dramatically with age. Protandim NAD goes beyond simply supplementing NAD. It activates the sirtuin pathways directly, targeting the real goal: longer healthspan at the cellular level.
🧠
Mental Clarity
Sharper focus, faster recall, less brain fog. Sirtuin activity supports healthy cognitive function at the cellular level.*
😊
Mood + Motivation
Sirtuins influence neurotransmitter pathways tied to mood, motivation, and emotional resilience.*
🔋
Sustained Energy
Not the spike-and-crash of stimulants. NAD-driven cellular energy is steady, clean, and systemic.*
🛡️
Healthy Inflammation
Sirtuins regulate the body’s inflammatory response — one of the most critical markers of healthy aging.*
♻️
Cellular Longevity
Sirtuins support autophagy — the cellular waste removal process linked to healthy aging and longevity.*
THE ANTI-AGING TRIFECTA
Three pathways. One complete system.
NRF2 fights oxidative damage. NRF1 powers the mitochondria. NAD activates longevity. Together they form the most comprehensive cellular activation system available anywhere in the world.
Protandim NRF2
THE LITTLE YELLOW ACTIVATOR
- Reduces oxidative stress by an average of 40% in 30 days*
- Activates NRF2 protein to trigger natural antioxidant production*
- Neutralizes up to 1,000,000 free radicals per second*
- Supports normal cellular repair and rejuvenation*
- Protects cells from free radical damage*
Protandim NRF1
THE POWER ACTIVATOR · MITOCHONDRIAL HEALTH
- Activates NRF1 protein to trigger mitochondria production*
- Increases cellular energy (ATP) for peak performance*
- Enhances mitochondrial networking and efficiency*
- Supports energy levels, focus, and recovery*
- Protects existing mitochondria from damage and decay*
Protandim NAD
THE LONGEVITY ACTIVATOR
- Doubles sirtuin production*
- Supports focus, mood, and energy*
- Healthy inflammatory response*
- Goes Beyond NAD — targets sirtuins directly*
Real Customers. Real Results.
I am without a doubt Protandim NRF2, Protandim NAD and Axio for life. My sleep is better than ever and my recovery is great. Better mood. I feel like I have better sleep. More energy. Clearer skin. What do you have to lose?
Don’t laugh, but when I added NAD I could do more of my crosswords. I just think clearer!
I feel like my inflammation may have gone down. I believe my pain would be so much worse without it. I’m 70 years old and I feel so good.
This is the only product my husband can’t live without. Helps him function better mentally during long 12-14 hour days!
NAD helps me Internmittent Fast even better. I notice an immediate difference in the stamina of my tough workouts. Together with NRF2 and NRF1, I HAVE to have it.
My brain fog is clearing. Everyone my age blames their hormones, this just proves there is something to help out there.. beyond the typical Pharma route…
NAD + Sirtuins: Breaking News in Science
Protandim NAD Synergizer FAQ
What is Protandim NAD Synergizer?
Protandim NAD Synergizer is specifically formulated to activate important proteins called sirtuins. Sirtuins deliver whole-body benefits, such as support for healthy longevity, the body’s healthy inflammatory response, joint health, a healthy vascular system, and more. It also provides immediate benefits for energy, mood, and focus.*
What is the difference between NRF2, NRF1, and NAD? How do they work together?
Protandim Nrf2 and NRF1 Synergizers work together to reduce oxidative stress and support mitochondria biogenesis and function.
With the addition of NAD Synergizer, we can now target other biochemical pathways known to support healthy aging and increased health span.
Can I take this at the same time as my other LifeVantage products?
Yes. Take two capsules daily, do not take wthin six hours of bedtime.
What does it mean BEYOND NAD on the label?
NAD is essential for sirtuin activity throughout the entire body and sirtuin activity declines with age. Protandim® NAD SynergizerTM supports the expression of genes that are part of signaling pathways to activate NAD-dependent enzymes and increase sirtuin activity.
Therefore moving beyond NAD and into the real goal–sirtuin activity.
.
PROPER DISCLOSURES: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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